Prof. Dr. Xiaomin Zhang
Area of Research
Description of Research Interest
Episodic memory is a remarkable cognitive function that allows us to recall specific life events with details of when and where they occurred. However, these initial memories are often fragile and require consolidation for long-term retention. Yet the neural mechanisms through which episodic memories are consolidated in the brain remain largely unknown. In our research group, our primary focus is to uncover the cellular and circuitry mechanisms that underlie episodic memory consolidation in the hippocampus. Employing advanced in vivo electrophysiological recordings and optical tools, we investigate single-neuron dynamics, neuronal population coding properties, and the role of neuromodulation during spatial memory consolidation. Our ultimate goal is to gain a comprehensive understanding of the neuronal mechanisms that contribute to impaired episodic memory formation, which is a key feature of early-onset Alzheimer's disease.Special Expertise
- In vivo electrophysiological recordings in awake, behaving animals
- Fiber photometry recordings
- Analysis of brain oscillations
Shareable Platforms, Services, Equipment & Infrastructure
- In vivo whole-cell patch-clamp recording techniques
- High-density extracellular electrode recording in behaving animals
- Ripple detection and analysis
Brain Research Institute