Prof. Dr. Ori Bar-Nur

Area of Research

Description of Research Interest

The Laboratory of Regenerative and Muscle Biology (RMB) was launched in 2018 as part of the Department of Health Sciences and Technology (D-HEST) at ETH Zurich. The lab's primary scientific interest and long-term goal is to develop stem cell-based therapeutic approaches to treat degenerative loss of muscle mass associated with muscular dystrophies, age-related muscle wasting, and more. To this end, the lab employs state-of-the-art transgenic models, direct reprogramming methods as well as muscle stem cells cultured  in vitro  to dissect the molecular drivers that orchestrate myogenic reprogramming and skeletal muscle regeneration. The lab is especially interested in elucidating the genetic and epigenetic changes that occur during cellular reprogramming, and the roles transcription factors and signaling pathways play during the regeneration course.