Prof. Dr. rer. nat. Benjamin Schuler

Area of Research

Description of Research Interest

We investigate the structure, dynamics, and functions of biomolecules with single-molecule spectroscopy. In particular, we focus on systems with pronounced conformational heterogeneity that is difficult to resolve with other techniques. Examples are intrinsically disordered proteins (IDPs), protein-nucleic acid interactions, protein misfolding, or the behavior of proteins inside live cells. A key goal of our work is to reach mechanistic understanding based on quantitative physical models.

Special Expertise

• Single-molecule spectroscopy
  
• Förster resonance energy transfer (FRET)
  
• Fluorescence
  
• Fluorescence correlation spectroscopy (FCS)