Prof. Dr. Andreas Hierlemann
Area of Research
Description of Research Interest
The research, in general, is rooted in Physics and in the Engineering disciplines and is targeted at developing and applying microtechnological, microfluidic, and microelectronic technologies to address questions in biology and medicine. Applications of the technologies are in the fields of systems biology, drug testing, personalized medicine, and neuroscience. For details, see the group Research pages.
Special Expertise
(1) CMOS MicrosystemsMicrotransducers are integrated in complementary-metal-oxide-semiconductor (CMOS) technology with dedicated analog and digital circuitry units in complex microsystems. The systems include microelectrode and biosensor systems.
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(2) Microfluidic and Microphysiological SystemsMicrofluidic and microphysiological systems are developed to recapitulate organs (e.g., liver, heart, pancreas) and physiological barriers (e.g., blood-brain barrier, lung, bladder, placenta) on chips for advanced in-vitro testing. The microtissue-based and barrier systems are characterized and analyzed by means of, e.g., impedance spectroscopy or high-resolution microscopy.
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(3) Electrophysiology and NeurosciencePreparations of electro-active cells, predominantly brain cells, are placed directly atop fully processed high-density microelectrode arrays (HD-MEAs) featuring thousands of electrodes. The HD-MEAs are used - also in combination with patch clamp and confocal microscopy - to address fundamental questions in neuroscience and medicine.
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Shareable Platforms, Services, Equipment & Infrastructure
Microtechnological cleanroom (Department BSSE)
Member of Collaborative/interdisciplinary Research Consortia
NCCR "Antiresist"
